AIDS vaccine researcher hopeful

A leader in the search for a vaccine against HIV, which causes AIDS, said that recent advances have given scientists new reason for hope.

Dr. Alan Bernstein, executive director of the Global HIV Vaccine Enterprise, cited the world’s first successful test of an experimental AIDS vaccine. In September, researchers said the vaccine protected one in three people from getting HIV in a large study in Thailand.

Dr. Bernstein also pointed to recent progress in determining whether people with HIV produce antibodies that could lead to a vaccine guarding against a variety of forms of HIV. He also said there is progress in mapping the many variations of what he called a “clever virus” that has so far eluded vaccine efforts because it kills some of the key cells needed to make a vaccine.

“This is a very exciting time in the field,” Dr. Bernstein said. “A vaccine is possible, and we have the scientific tools now to turn that possibility into a reality.”

Though he said the research effort has turned a corner after several setbacks, he cautioned a vaccine was still several years away.

Others are far less optimistic.

“I wish I could say I was. But I’m not,” said Salim Karim, director of the Centre for the AIDS Programme of Research in South Africa.

“It’s proving to be a challenge that’s more complex than previously thought,” he said, adding he has spent 15 years researching a vaccine, and expected success to take at least another 15.

Karim called the Thai study a “glimmer.” Scientists must now try to improve the vaccine so that it protects more than a third of the people who get it, and lasts for more than the six to 12 months it now appears to be effective.